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Sharon R. Browning

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Sharon R. Browning
Born1973
Alma materUniversity of Washington
Scientific career
ThesisMonte Carlo likelihood calculation for identity by descent data (1999)
Doctoral advisorElizabeth A. Thompson

Sharon Ruth Browning is a statistical geneticist at the University of Washington,[1] and a research professor with its Department of Biostatistics.[2][3][4] Her research has various implications for the field of biogenetics.

Education and career

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Browning has a B.Sc. from the University of Auckland (1995) and earned her Ph.D. in 1999 from the University of Washington.[5] Following her Ph.D., she held positions at Texas A&M University, North Carolina State University, GlaxoSmithKline, and the University of Auckland before moving to the University of Washington in 2010.[6]

Research

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Browning is known for her research developing statistical methods for analysis of population genetic data. Her early work established the used of Markov chain modeling to examine association based genome mapping.[7] Her work addresses how to handle missing data in whole-genome association studies.[8][9] She has also defined the use of group association tests[10] and examined relatedness of individuals based on shared gene content.[11][12] Browning has also examined the genetic history of the Samoans.[13][14]

Browning and her research group also study the traces of genetic introgression from archaic humans into modern human DNA. In 2018, they discovered that humans in the distant past had mated with Denisovans in at least two separate events, the second of which may have occurred as humans migrated eastward into Asia and Oceania.[15][16][17]

Selected publications

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  • Browning, Sharon R.; Browning, Brian L. (2007). "Rapid and Accurate Haplotype Phasing and Missing-Data Inference for Whole-Genome Association Studies By Use of Localized Haplotype Clustering". The American Journal of Human Genetics. 81 (5): 1084–1097. doi:10.1086/521987. PMC 2265661. PMID 17924348.
  • Browning, Brian L.; Browning, Sharon R. (2009). "A Unified Approach to Genotype Imputation and Haplotype-Phase Inference for Large Data Sets of Trios and Unrelated Individuals". The American Journal of Human Genetics. 84 (2): 210–223. doi:10.1016/j.ajhg.2009.01.005. PMC 2668004. PMID 19200528.
  • Madsen, Bo Eskerod; Browning, Sharon R. (2009-02-13). "A Groupwise Association Test for Rare Mutations Using a Weighted Sum Statistic". PLOS Genetics. 5 (2): e1000384. doi:10.1371/journal.pgen.1000384. ISSN 1553-7404. PMC 2633048. PMID 19214210.

References

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  1. ^ Zimmer, Carl (2018-08-22). "A Blended Family: Her Mother Was Neanderthal, Her Father Something Else Entirely". The New York Times. ISSN 0362-4331. Retrieved 2019-04-05.
  2. ^ Dvorsky, George (15 March 2018). "Ancient Human Groups Mated With the Mysterious Denisovans at Least Twice". Gizmodo. Retrieved 2019-04-05.
  3. ^ "Mysterious Denisovans interbred with modern humans more than once". CNN. 16 March 2018. Retrieved 2018-03-16.
  4. ^ "Modern humans interbred with Denisovans twice in history". Retrieved 2018-03-15.
  5. ^ Browning, Sharon (1999). Monte Carlo likelihood calculation for identity by descent data (Thesis thesis).
  6. ^ "Browning CV" (PDF). Retrieved December 19, 2021.
  7. ^ Browning, Sharon R. (2006-06-01). "Multilocus Association Mapping Using Variable-Length Markov Chains". The American Journal of Human Genetics. 78 (6): 903–913. doi:10.1086/503876. ISSN 0002-9297. PMC 1474089. PMID 16685642.
  8. ^ Browning, Sharon R.; Browning, Brian L. (2007). "Rapid and Accurate Haplotype Phasing and Missing-Data Inference for Whole-Genome Association Studies By Use of Localized Haplotype Clustering". The American Journal of Human Genetics. 81 (5): 1084–1097. doi:10.1086/521987. PMC 2265661. PMID 17924348.
  9. ^ Browning, Sharon R. (2008). "Missing data imputation and haplotype phase inference for genome-wide association studies". Human Genetics. 124 (5): 439–450. doi:10.1007/s00439-008-0568-7. ISSN 0340-6717. PMC 2731769. PMID 18850115.
  10. ^ Madsen, Bo Eskerod; Browning, Sharon R. (2009-02-13). Schork, Nicholas J. (ed.). "A Groupwise Association Test for Rare Mutations Using a Weighted Sum Statistic". PLOS Genetics. 5 (2): e1000384. doi:10.1371/journal.pgen.1000384. ISSN 1553-7404. PMC 2633048. PMID 19214210.
  11. ^ Browning, Sharon R.; Browning, Brian L. (2012-12-15). "Identity by Descent Between Distant Relatives: Detection and Applications". Annual Review of Genetics. 46 (1): 617–633. doi:10.1146/annurev-genet-110711-155534. ISSN 0066-4197. PMID 22994355.
  12. ^ Browning, Sharon R.; Browning, Brian L. (2010). "High-Resolution Detection of Identity by Descent in Unrelated Individuals". The American Journal of Human Genetics. 86 (4): 526–539. doi:10.1016/j.ajhg.2010.02.021. PMC 2850444. PMID 20303063.
  13. ^ Harris, Daniel N.; Kessler, Michael D.; Shetty, Amol C.; Weeks, Daniel E.; Minster, Ryan L.; Browning, Sharon; Cochrane, Ethan E.; Deka, Ranjan; Hawley, Nicola L.; Reupena, Muagututi‘a Sefuiva; Naseri, Take (2020-04-28). "Evolutionary history of modern Samoans". Proceedings of the National Academy of Sciences. 117 (17): 9458–9465. Bibcode:2020PNAS..117.9458H. doi:10.1073/pnas.1913157117. ISSN 0027-8424. PMC 7196816. PMID 32291332.
  14. ^ "Researchers use 21st century genomics to estimate Samoan population dynamics over 3,000 years". Brown University. Retrieved 2021-12-23.
  15. ^ "Multiple lines of mysterious ancient humans interbred with us". Science. 2019-04-11. Retrieved 2021-12-23.
  16. ^ Guarino, Ben (March 15, 2018). "Humans bred with this mysterious species more than once, new study shows". Washington Post. ISSN 0190-8286. Retrieved 2021-12-23.
  17. ^ Browning, Sharon R.; Browning, Brian L.; Zhou, Ying; Tucci, Serena; Akey, Joshua M. (2018). "Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture". Cell. 173 (1): 53–61.e9. doi:10.1016/j.cell.2018.02.031. PMC 5866234. PMID 29551270.
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